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Furthermore, the concentration of methotrexate in target tissues can be reduced by macrophage phagocytosis (94)

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Despite limited value of individual tau protein biomarkers in the early diagnosis of PD, the t-tau/t--Syn ratio, when combined with t--Syn levels in CSF, can greatly increase the accuracy of early PD diagnosis by allowing for better differentiation from AD or DLB (Frland et al., 2020)